Name: Hovilpri (pritelivir) in Refractory mucocutaneous herpes simplex virus infection in immunocompromised adults: Dosage forms and strengths
Published: 2026-10-11T11:04:25-04:00

Tablet strength and appearance

“Tablets: 100 mg of pritelivir.” (opens the prescribing information at this quote)
“HOVILPRI film-coated tablets are white to off-white, round, biconvex and contain 100 mg pritelivir.” (opens the prescribing information at this quote)
“The tablets are embossed with ‘AIC’ on one side and with ‘1’ on the other side.” (opens the prescribing information at this quote)
“HOVILPRI 100 mg tablets are white to off-white film-coated tablets.” (opens the prescribing information at this quote)
“The tablets are round and biconvex with a diameter of about 11 mm, debossed with “1” on one side and “AIC” on the other side and with weight of 513 mg.” (opens the prescribing information at this quote)

Salt form and pritelivir content per tablet

“Each tablet contains 100 mg of pritelivir (equivalent to 123.9 mg of pritelivir mesylate) and is available as immediate release tablets for oral administration.” (opens the prescribing information at this quote)
“HOVILPRI (pritelivir), a helicase-primase inhibitor, is developed as a mesylate monohydrate salt.” (opens the prescribing information at this quote)

Inactive ingredients

“The tablet core contains standard excipients: colloidal silica dioxide, croscarmellose sodium, magnesium stearate, mannitol, and microcrystalline cellulose, as well as the film-coat (hydroxy propyl methyl cellulose and polyethylene glycol) and the colorant/opacifier calcium diphosphate.” (opens the prescribing information at this quote)
“Inactive ingredients: colloidal silica dioxide, croscarmellose sodium, magnesium stearate, mannitol, and microcrystalline cellulose. The film-coat contains hydroxy propyl methyl cellulose and polyethylene glycol, and calcium diphosphate.” (opens the prescribing information at this quote)

Packages and national drug codes

Package	NDC	Contents
Carton of 32 tablets	“NDC 68992-100-32”	“Each carton contains two blister wallets. Each blister wallet contains 16 film-coated tablets, for a total of 32 film-coated tablets per carton.”
Carton of 16 tablets	“NDC 68992-100-16”	“Each carton contains one blister wallet containing 16 film-coated tablets.”

“HOVILPRI is available in cartons of 16 or 32 film-coated tablets.” (opens the prescribing information at this quote)

Storage

“Store at 20°C to 25°C (68°F to 77°F), excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].” (opens the prescribing information at this quote)
“Keep HOVILPRI and all medicines out of the reach of children.” (opens the prescribing information at this quote)

Selection of the mesylate monohydrate solid form during development

“During preliminary polymorphism studies of the mesylate salt, 9 different XRPD (X-ray powder diffraction) patterns (mainly solvates) were discovered.” (opens the source at this quote in a new tab)
“In addition, the selected salt form shows a very long stability.” (opens the source at this quote in a new tab)

Pharmaceutical form and planned oral suspension in the European Union paediatric investigation plan

“A paediatric investigation plan for pritelivir (mesylate monohydrate), film-coated tablet, oral use, gastric use, the details of which are set out in the opinion of the Paediatric Committee of the European Medicines Agency annexed hereto, together with its appendices, is hereby agreed.” (opens the source at this quote in a new tab)
“Development of an oral suspension prepared from the film-coated tablets.” (opens the source at this quote in a new tab)

Other formulations studied: topical pritelivir

“Pritelivir (topical), designed for the treatment of recurrent labial herpes (mainly HSV-1), is currently in a clinical phase 2 trial, following successful phase 1 results.” (opens the source at this quote in a new tab)

Material safety data sheet

No evidence found.