Product information and disease description Place of product in therapy Disease description Burden of Refractory mucocutaneous herpes simplex virus infection in immunocompromised adults

Humanistic burden and health-related quality of life

3 evidence topics · 3 sources

Health-related quality of life measured with a validated instrument in refractory or resistant infection

No evidence found.

Duration of lesional pain in the five-center United States foscarnet cohort

“Assessment of pain related to the HSV infection was reported in 17 of 31 episodes (55%). The number of days of pain relative to the total duration of the episode in days per patient ranged from 2% to 100% with a median of 100% and a mean of 88% in the group where pain data were available. Pain cessation was reported in 5 of 17 episodes at a median on 74 days.” (opens the source at this quote in a new tab)
“Lesion measurements and pain scales were not consistently serially recorded, as these would be in the context of a clinical trial.” (opens the source at this quote in a new tab)

Oral intake, analgesia, and quality of life as described by cohort investigators

“Severe oral HSV infections may impede adequate oral intake and require hospitalization for hydration, analgesics, and intravenous (IV) antiviral therapy, adversely impacting patients' quality of life and increasing health care resource utilization.” (opens the source at this quote in a new tab)
“Effective, safer, and orally bioavailable therapies are critically needed to improve the quality of life of HCT patients with refractory HSV infections” (opens the source at this quote in a new tab)

Proxy evidence: systematic review of health-related quality of life in genital herpes, with 1 of 19 primary studies in people living with HIV

“This systematic review aimed to identify studies that quantitatively evaluated the effect of genital herpes on various aspects of health-related quality of life.” (opens the source at this quote in a new tab)
“We identified 26 relevant publications: 19 presented primary quality of life data, and seven were economic evaluations. The primary studies presented a range of condition-specific tools for describing the quality of life in individuals with genital herpes, but only one study used a direct valuation that could be used to generate utility weights.” (opens the source at this quote in a new tab)
“The extant literature on genital herpes-related quality of life is limited and requires updating.” (opens the source at this quote in a new tab)